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Descriptor English: Complement C3
Descriptor Spanish: Complemento C3
Descriptor complemento C3
Scope note: Glicoproteína central tanto en la vía clásica como alternativa de la ACTIVACIÓN DEL COMPLEMENTO. C3 puede ser desdoblada en COMPLEMENTO C3A y COMPLEMENTO C3B, espontáneamente a bajo nivel o por la CONVERTASA C3 a alto nivel. El fragmento C3a más pequeño es una ANAFILATOXINA y mediador en el proceso inflamatorio local. El fragmento C3b de mayor tamaño se une a la convertasa C3 para formar convertasa C5.
Descriptor Portuguese: Complemento C3
Descriptor French: Complément C3
Entry term(s): C3 Complement
C3 Precursor
C3 Precursor, Complement
C3, Complement
Complement 3
Complement C3 Precursor
Complement Component 3
Complement, C3
Component 3, Complement
Precursor Complement 3
Precursor, C3
Precursor, Complement C3
Precursor-Complement 3
Pro C3
Pro Complement 3
Pro-C3
Pro-Complement 3
Tree number(s): D12.776.124.050.140
D12.776.124.486.274.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003176
Scope note: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Anaphylaxis (1966-1974)
Chemotaxis (1966-1974)
Complement (1968-1974)
Immune Adherence Reaction (1971-1974)
Neutrophils (1966-1974)
Phagocytosis (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 3 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C3 PRECURSOR was indexed under COMPLEMENT 3 1982-2005
History Note: 2006 (1975)
DeCS ID: 22135
Unique ID: D003176
NLM Classification: QW 680
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/07/11
Complement C3 - Preferred
Concept UI M0004928
Scope note A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Preferred term Complement C3
Entry term(s) C3 Complement
C3, Complement
Complement 3
Complement Component 3
Complement, C3
Component 3, Complement
Complement C3 Precursor - Broader
Concept UI M0102971
Preferred term Complement C3 Precursor
Entry term(s) C3 Precursor
C3 Precursor, Complement
Precursor Complement 3
Precursor, C3
Precursor, Complement C3
Precursor-Complement 3
Pro C3
Pro Complement 3
Pro-C3
Pro-Complement 3



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